Wenqing Chen, Ph.D
Associate Professor
185 Donghu Road, Wuhan 430071, China.
Key Laboratory of Combinatorial Biosynthesis
and Drug Discovery, Ministry of Education
School of Pharmaceutical Sciences
Wuhan University Wuhan, China
Tel：+86-27-68756713
Email：wqchen@whu.edu.cn
Education & Work Experience:
1995-1999，Anhui University of Science & Technology, Ba. Eng. Food Science and Engineering
2001-2004, Huazhong Agricultural University, MA.Sc, Microbiology
2005-2009, Shanghai Jiao Tong University, Ph.D Microbiology
2009-2010, Shanghai Jiao Tong University, Research Associate
2013-2014, University of California, Los Angeles (UCLA), Postdoctor
2011-Now, Wuhan University, Associate Professor.
Research Interest:
1. Synthetic biology and biosynthesis of nucleoside antibiotics.
2. Target-directed genome mining for novel nucleoside antibiotics discovery.
3. Biosynthesis-inspired biomanufacturing for pharmaceuticals/chemicals.
Selected Pbulication：
1. Chen W, Qi J, Wu P, Wan D, Liu J, Deng Z. (2015) Natural and e ngineered biosynthesis of nucleoside antibiotics in Actinomycetes. J Ind Microbiol & Biot, DOI: 10.1007/s10295-015-1636-3.
2. Qi J, Liu J, Wan D, Wang Y, Cai Y, Feng X, Wu P, Li S, Qiu G, Yang S, Chen W*, Deng Z. (2015) Metabolic engineering of an industrial polyoxin producer for the targeted overproduction of designer nucleoside antibiotics. Biotechnol Bioeng. 112(9):1865-71. (*Corresponding author) (Featured as Spotlight in Biotechol Bioeng)
3. Price NP, Furukawa T, Cheng F, Qi J, Chen W, Crich D. (2014) Biosynthesis of 4-aminoheptose 2-epimers, core structural components of the septacidins and spicamycins. J Antibiot (Tokyo). 67(5):405-14.
4. Xu T, Yu D, Xu P, Xu W, Chen W, Chen C, Li X. (2014) Real-time enzyme-digesting identification of double-strand DNA in a resonance-cantilever embedded micro-chamber. Lab Chip. 14(6):1206-14.
5. Chen W, Dai D, Wang C, Huang T, Zhai L, Deng Z. (2013) Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networks. Microb Cell Fact. 12:121.
6. Xu D, Liu G, Cheng L, Lu X, Chen W*, Deng Z*. (2013) Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL30471. PLoS One. 8(10):e76068 (*Co-corresponding author)
7. Zhai L, Lin S, Qu D, Hong X, Bai L, Chen W*, Deng Z*. (2012) Engineering of an Industrial Polyoxin Producer for the Rational Production of Hybrid Peptidyl Nucleoside Antibiotics. Metab Eng. 14(4):388-93. (*Co-corresponding author)
8. Doroghazi J, Ju K, Brown D, Labeda D, Deng Z, Metcalf W, Chen W*, Price N*. (2011) Genome sequences of three tunicamycin-producing Streptomyces strains; S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396. J Bacteriol. 193(24):7021-2. (*Co-corresponding author)
9. Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z. (2011) Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem. 286(23):20648-57.
10. Cheng L, Chen W*, Zhai L, Xu D, Huang T, Lin S, Zhou X, Deng Z*. (2011) Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471. Mol Biosyst. 7(3):920-927. (*Co-corresponding author)
11. Chen W*, Qu D*, Zhai L, Tao M, Wang Y, Lin S, Price NP, Deng Z. (2010) Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis. Protein & Cell. 1(12):1093-1105. (*Co-first author)
12. Zhao C, Huang T, Chen W, Deng Z. (2010) Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster. Appl Environ Microbiol. 76(21):7343-7347.
13. Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z. (2009) Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H. J. Biol. Chem. 284(16): 10627-10638.
14. Sun L, Chen W, Deng Z, Zhong J. (2009) Microbiological assay for quantitative determination of polyoxin B. Process Biochemistry. 44, 361-364.
15. Li R, Xie Z, Tian Y, Yang H, Chen W, You D, Deng Z, Tan H. (2009) polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi var. asoensis. Microbiol-SGM. 155, 1819-1831.
16. Li R, Liu G, Xie Z, He X, Chen W, Deng Z, Tan H. (2009) PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi. Mol Microbiol. 75(2): 349-364.
