Name: Wei Wang

Subjects：Medicinal Chemistry

Department: Medicinal Chemistry

College appointment: Pharmaceutical Sciences

Email: waw6@whu.edu.cn

Telephone:027-68759586

Fax:027-68759850

 

◆Background/Biography:

·Education:

9/2000-6/2005    Ph.D. Candidate in Chemistry, Wuhan University

7/1996-7/2000    B.S. in Chemistry, Wuhan University

 

Short Course

3/2010                An Interactive Workshop of Process Chemistry in the Pharmaceutical Industry By Dr. Kumar Gadamasetti, Department of Chemistry, University of Pittsburgh, USA

9/2009-12/2009  Medicinal Chemistry (School of pharmacy in University of Pittsburgh), USA

3/2009-7/2009    MCR Course (School of pharmacy in University of Pittsburgh)

8/2004-9/2004    Theoretical and Computational Chemistry, Metal Organic Chemistry, Peking University, Peking, China

 

·Honors & Awards：

2011 The “Chunhui Cup” Innovation and Entrepreneurship Competition Award

2009 The Combinatorial Chemistry Gordon Research (including Gordon-Kenan Research Seminar ) Travel Award

2006 Merck Awards for Innovation in WuXi PharmaTechs

◆Teaching:

Undergraduate and Graduate Course: Computer Aided Drug Design

Graduate Course: Modern Drug Discovery&Development and IND&NDA Filing

 

◆Research interests:

1. Focusing on the structure information mining on disease related target, virus infection pathway, combining with novel chemical synthesis database analysis, performing the design, synthesis and evaluation of peptide mimetics and small molecules.

2. Mainly studying on protein-protein interaction target drug discovery, such as the tumor apoptosis pathway targets( Bcl-2, XIAP, mdm2 etc. ), infectious disease target such as HIV-1 capsid assembly process drug design, influenza M2 target.

3. Medicinal chemistry methodology

◆Publications:

[1]       Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors, Shuwen Wu, Jing Huang, Sabrina Gazzarrini, Si He, Lihua Chen, Dr. Jun Li, Li Xing, Chufang Li, Ling Chen, Constantinos G. Neochoritis, George P. Liao, Haibing Zhou, Alexander Dömling, Anna Moroni, Wei Wang*,CHEMMEDCHEM, 2015, 10(11), 1837-1845

[2]       Progess in the study of HIV capsid structure and drug discovery, Jun Li, Wei Wang, Acta Pharmaceutical Sinica(Chinese edition), 2015, 50(9), 1088-1095

[3]      Recyclable BINOL–quinine–squaramide as a highly efficient organocatalyst for α-amination of 1,3-dicarbonyl compounds and α-cyanoacetates, Yongzhi Gao, Bin Liu, Hai-Bing Zhou, Wei Wang, Chune Dong*, RSC Advances, 2015, 31(5), 24392-24398

[4]      Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors, Xin Han, Haoming Wu, Wei Wang, Chune Dong, Po Tien, Shuwen Wu*, Hai-Bing Zhou*, Organic Biomolecular Chemistry, 2014, 41(12), 8308-8317

[5]     (3+2) Annulation of Amidinothioureas with Binucleophile: Synthesis and Antimicrobial Activity of 3-Phenylamino-5-aryl/alkyl-1,2,4-oxadiazole Derivatives, Swapnil G. Yerande, Amruta B. Ghaisas, Kiran M. Newase, Wei Wang, Kan Wang, Alexander Dömling, Journal of Heterocyclic Chemistry, 2014, 51(6), 1752-1756

[6]        Mercury(II) Chloride-Mediated Desulphurization of Amidinothioureas: Synthesis andAntimicrobial Activity of 3-Amino-1,2,4-triazole Derivatives, Swapnil G. Yerande, Chetna D. Baviskar, Kiran M. Newase, Wei Wang, Kan Wang, Alexander Dömling, Journal of Heterocyclic Chemistry, 2014, 51(6), 1883-1887

[7]        Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts, Xin Han, Wenjie Ouyang, Bin Liu, Wei Wang*, Bo Tian , Shuwen Wu *, Hai-Bing Zhou*, Organic Biomolecular Chemistry, 2013, 40(11), 8463-8475

[8]       N-Butyl-2,4-dinitro-anilinium p-toluenesulfonate as a highly active and selective esterification catalyst, Narsimha Sattenapallya, Wei Wang, Huimin Liu, and Yong Gao*, Tetrahedron Letters, 2013, 54(48), 6665-6668

[9]       Esterification Catalysis by Pyridinium p-Toluenesulfonate Revisited Modification with a Lipid Chain for Improved Activities and Selectivities, Wei Wang, Huimin Liu, Shaoyi Xu, and Yong Gao*, Synthetic Communications, 2013, 43(21), 2906-2912

[10]     Benzimidazole-2-one: A novel anchoring principle for antagonizing p53-Mdm2, Wei Wang, Haiping Cao, Siglinde Wolf, Miguel S. Camacho-Horvitz, Tad Holak, and Alexander Dömling, Bioorganic & Medicinal Chemistry, 2013, 21(14), 3982-3995.

[11]    Chemisty & Biology of Multicomponent Reactions, Alexander Dömling*, Wei Wang, Kan Wang, , Chemical Reviews, 2012, 112 (6), pp 3083

[12]     Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists, D. Koes, K. Khoury, Y. Huang, Wei Wang, M. Bista, G. M. Popowicz, S. Wolf , T. A. Holak, A. Dömling, C.J. Camacho, Plos One, 2012 , 7(3), e32839

[13]     Polycyclic Compounds by Ugi−Pictet−Spengler Sequence U, Wei Wang, Sarah Ollio, Alexander Dömling, The Journal of Organic Chemistry, 2011, 76 (2), 637–644, (Selected by Synfact, 2011, 4, 376)

[14]    Two Strategies for the Development of Mitochondrial-Targeted Small Molecule Radiation Damage Mitigators,U  Jean-Claude M. Rwigema,  Barbara Beck, Wei Wang, Alexandaer Domling, Michael W. Epperly, Donna Shields,  Darcy Franicola,  Tracy Dixon, Marie-Celine Céline Frantz, Peter Wipf,  Yulia Tyurina,  Valerian Kagan, Hong Wang, and Joel S. Greenberger, International Journal of Radiation Oncology*Biology*Physics, 2011, 80(3), 860-868,

[15]     Structures of Low Molecular Weight Inhibitors Bound to MDMX and MDM2 Reveal New Approaches for p53-MDMX/MDM2 Antagonist Drug DiscoveryUH, G. M. Popowicz, A. Czarna, S. Wolf, K. Wang, Wei Wang, A. Dömling, T. A. Holak, Cell Cycle, 2010, 9(6), 1104 – 1111.

[16]   Polycylic Library by MCR and Pictet-Splendor ReactionUH, Wei Wang, Eberhardt Herdtweck , Alexander Dömling, Chemical Communications, 2010, 46, 770-772.

[17]     Bacillamide C and Derivatives: The Convergent ApproachUH, Wei Wang, Shannon Joyner, Kareem Andrew Sameer Khoury, Alexander Dömling, Organic Biomolecular Chemistry, 2010, 8, 529-532.

[18]     Rapid and efficient hydrophilicity tuning of p53/MDM2 antagonistsUH, Stuti Srivastava, Barbara Beck, Wei Wang, Ania Czarna, Tad Holak, Alexander Dömling, Journal of Combinatorial Chemistry, 2009, 11 (4), pp 631–639,

[19]     Efficient Synthesis Of Arrays Of Amino Acid Derived Ugi Products With Subsequent AmidationUH, Wei Wang, Alexander Dömling, Journal of Combinatorial Chemistry, 2009, 11 (3), p 403-409