Title: The Mitochondrial Electron Transport Chain as Emerging Target for Cancer Therapy

Speaker: Dr. Dieter Wolf August, Xiamen University, A Foreign 1000 Talents Professor

Time: 10:00 a.m., Nov. 17, 2015

Site: No.712 Meeting Room, School of Pharmaceutical Sciences

Dieter Wolf August

Biography:

Dr. Wolf studied medicine at the University in Munich, Germany. After postdoctoral work at Harvard Medical School and Stanford University School of Medicine, he joined the Department of Cancer Cell Biology at Harvard as an Assistant Professor in 1998. In 2007, Dr. Wolf moved to Sanford-Burnham Medical Research Institute as Professor and Director of Proteomics. In 2015, Dr. Wolf was recruited to Xiamen University’s School of Pharmaceutical Sciences as a Foreign 1000 Talents Professor.

Research Interest

Dr. Wolf’s research focuses on protein quality control and associated stress response pathways and their utility as cancer drug targets. Among the most significant achievements were the identification of BTB proteins as substrate adapters of cullin3-based ubiquitin ligases and studies on the regulation of cullin-RING ubiquitin ligases by deneddylation. At Xiamen University, Dr. Wolf’s lab will focus on castration-resistant prostate cancer - a major health issue in China and beyond - establishing patient-derived xenograft models, in vivo loss-of-function screens, and cancer proteomics for the identification of novel drug targets. A second focus concerns mechanisms controlling protein synthesis, their roles in cancer, and their potential as novel drug targets.