Name: Tiangang Liu
Subjects：Microbial and Biochemical Pharmacy
Department: School of Pharmaceutical Sciences
College appointment: Professor
Email: liutg@whu.edu.cn
Telephone: +86-27-68755086
Fax: +86-27-68755086
Web-page: http://liugroup.whu.edu.cn
◆Background/Biography:
·Education:
2008 Ph.D. Microbiology, School of Life Science & Biotechnology, Shanghai Jiaotong University, China
2006 - 2007 As an exchange Ph.D student, Department of Chemistry, Brown University, USA
2002 B.S. Microbial engineering, Department of Biotechnology, Shandong University, China
·Honors & Awards：
2015 Outstanding Young scholar, China
2012 "Chutian scholar" Professor, Hubei, China
2012 Supported by National Natural Science Funds for Excellent Young Scholar, China
2010 New Century Excellent Talents in University, China
2006 National scholarship for excellent Ph.D student, Shanghai Jiaotong University, China
2000 The golden prize winner of the second "Challenge Cup" National College Student Business Plan Competition, China
◆Teaching: Synthetic Biology; Introduction to pharmacy; Biochemistry
◆Research interests: Metabolic engineering, the new biofuel and biological pharmacy
◆Publications:
1. Ma, T., Zhou, Y., Li, X., Zhu, F., Cheng, Y., Li. Y., Deng, Z., Liu, T. (2015). Genome mining of astaxanthin biosynthetic genes from Sphingomonas sp. ATCC 55669 for heterologous overproduction in E. coli. Biotechnology Journal. In press.
2. Tao, H., Guo, D., Zhang, Y., Deng, Z., Liu, T. (2015). Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property. Biotechnology for Biofuels.
3. Zhu, F., Lu, L., Fu, S., Zhong, X., Hu, M., Deng, Z., Liu, T. (2015). Targeted engineering and scale up of lycopene overproduction in Escherichia coli. Process Biochemistry. 50, 341-346.
4. Liu, Q., Wu, K., Lu, L., Cheng, Y., Zhang, Y., Deng, Z., Liu, T. (2015). Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. Metabolic Engineering. 28, 82-90.
5. Liu, R., Zhu, F., Lu, L., Fu, A., Lu, J., Deng, Z., Liu, T. (2014). Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metabolic engineering. 22, 10-21.
6. Guo, D., Zhu, J., Deng, Z., Liu, T. (2014). Metabolic Engineering of Escherichia coli for Production of Fatty Acid Short-Chain Esters through Combination of the Fatty Acid and 2-Keto Acid Pathways. Metabolic engineering. 22, 69-75
7. Li, X., Guo, D., Cheng, Y., Zhu, F., Deng, Z., & Liu, T. (2014). Overproduction of fatty acids in engineered Saccharomyces cerevisiae. Biotechnology and bioengineering. DOI: 10.1002/bit.25239
8. Zhu, F., Zhong, X., Hu, M., Lu, L., Deng, Z., & Liu, T. (2014). In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. Biotechnology and bioengineering. 111, 1396-1405
9. Wang, J., Nie, Y., Lu, Y., Liu, J., Wang, J., Fu, A., Liu, T. & Xia, J. (2014). Assembly of Multivalent Protein Ligands and Quantum Dots: A Multifaceted Investigation. Langmuir. 30, 2161–2169
10. Guo X, Liu T, Deng Z, Cane DE. (2012). Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase. Biochemistry. 51, 879-87
11. Yu Q, Du A, Liu T, Deng Z, He X. (2012). The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators. Arch Microbiol. 194, 415-26
12. Yu X, Liu T, Zhu F, Khosla C. (2011). In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proc Natl Acad Sci U S A. 108, 18643-8
13. Liu T, Khosla C. (2010). A Balancing Act for Taxol Precursor Pathways in E. coli. Science. 330, 44-45
14. Liu T, Vora H, Khosla C. (2010). Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metabolic Engineering. 12, 378-86
15. Liu T, Khosla C. (2010). Genetic Engineering of Escherichia coli for Biofuel production. Annual Review of Genetics. 44, 53-69
16. Xun G, Liu T, Valenzano C, Deng Z, Cane D. (2010). Mechanism and Stereospecificity of a Fully Saturating Polyketide Synthase Module: Nanchangmycin Synthase Module 2 and Its Dehydratase Domain. Journal of American Chemical Society. 132, 14694-6
17. He Y, Sun Y, Liu T, Zhou X, Bai L, Deng Z. (2010). Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification. Appl Environ Microbiol. 76, 3283-92
18. Liu T, Cane D, Deng Z. The Enzymology of Polyether Biosynthesis. (2009). Methods in Enzymology. 459, 187-214
19. Liu T, Lin X, Zhou X, Deng Z, Cane D. (2008). Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chemistry & Biology.15, 449-58
20. Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane D, Deng Z. (2006). Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis. Chemistry & Biology. 13, 945-55
BOOKS
1. Ning T, Liu T. (2014) Chapter 7: Engineering Microbial Fatty Acid Biosynthetic Pathways to Make Advanced Biofuels. Biofuels: From Microbes to Molecules. Caister Academic Press.
2. Liu Z, Liu T. (2013) Chapter 8: In vitro Reconstitution of Fatty Acid Biosynthesis System to Guide Industrialization of New Biofuels. 2013 Industrial biotechnology development report. Science Press.
