Name: Hai-Bing Zhou
Subjects: Medicinal Chemistry
Department: Wuhan University School of Pharmaceutical Sciences
College appointment: Professor/State Key Laboratory of Virology, Wuhan University School of Pharmaceutical Sciences
Email: zhouhb@whu.edu.cn
Telephone: 86-27-68759586 (O)
Fax: 86-27-68759850
Web-page:http://www.pharm.whu.edu.cn/NewsDetail.asp?MaxSort=szdw&MaxUrl=
teacher&id=184
◆Background/Biography:
Education:
1997/09-2000/07：Ph.D. in Organic Chemistry, Sichuan University, China.
1994/09-1997/07：M.S. in Organic Chemistry, Sichuan University, China.
1990/09-1994/07：B.S. in Chemistry, Yan’an University, China.
Work experience:
2007/09-present: Professor, Wuhan University School of Pharmaceutical Sciences, China.
2003/12-2007/11: Postdoctoral associate, University of Illinois at Urbana-Champaign, USA.
2001/09-2003/12: Postdoctoral fellow, University of Ottawa, Canada.
2000/08-2001/08: Research assistant, The University of Kong Kong, China.
Honors & Awards：
1. Chair Professor of Luojia Scholarship of Wuhan University in 2012.
2. The WuXi PharmaTech Life Science and Chemistry Award in 2010.
3. Selected for New Century Excellent Talents in 2009.
◆Teaching:
Advanced Organic Chemistry, Medicinal Chemistry.
◆Research interests:
Anti-virus/anti-tumor drugs discovery
◆Publications:
1) Novel Bioactive Hybrid Compounds Dual Targeting Estrogen Receptor and Histone Deacetylase for Treatment of Breast Cancer. Chu Tang, Changhao Li, Silong Zhang, Zhiye Hu, Jun Wu, Chune Dong*, Jian Huang*, and Hai-Bing Zhou*. J. Med. Chem. 2015, 58 (11), 4550-4572. (IF: 5.447) (One of Most Read Top 20 Articles of the Month; Highlighted by BioCentury Innovations (Formerly SciBX, Science-Business eXchange) on June 25, 2015)
2) Tunable Bifunctional Phosphine Squaramide Promoted Morita-Baylis-Hillman Reaction of N-alkyl Isatins with Acrylates. Ze Dong, Chao Yan, Yongzhi Gao, Chune Dong, Guofu Qiu*, Hai-Bing Zhou*. Adv. Synth. Catal. 2015, 357 (9), 2132–2142. (IF: 5.663).
3) Synthesis of N-benzyl-N-phenylthiophene-2-carboxamide Analogues as a Novel Class of Enterovirus 71 Inhibitors. Jiawei Pan, Xin Han, Ningyuan Sun, Haoming Wu, Dandan Lin, Po Tien, Hai-Bing Zhou* and Shuwen Wu*. RSC Adv., 2015, 5 (31), 55100-55108. (IF: 3.840)
4) Recyclable BINOL-Quinine-Squaramide as Highly Efficient Organocatalyst for α-Amination of 1, 3-Dicarbonyl Compounds and α-Cyanoacetates. Yongzhi Gao, Bin Liu, Wei Wang, Hai-Bing Zhouand Chune Dong*. RSC Adv., 2015, 5 (31), 24392-24396. (IF: 3. 840)
5) Halolactones are Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. X. Han, H. Wu, C. Dong, P. Tien, W. Xie, S. W. Wu*, H.-B. Zhou*. RSC Adv., 2015, 5 (13), 10005-10013. (IF: 3. 840)
6) Estrogen receptor-targeted fluorescent probes and bioapplications. Lu Yang, Chu Tang, Hai-Bing Zhou*. SCIENTIA SINICA Chimica 2015, 45 (9), 937–948.
7) Synthesis and SARs of Indole-based α-Amino Acids as Potent HIV-1 Non-Nucleoside Reversed Transcriptase Inhibitors. Xin Han, Haoming Wu, Wei Wang, Chune Dong, Po Tien, Shuwen Wu*, Hai-Bing Zhou*. Org. Biomol. Chem., 2014, 12 (41), 8308 - 8317. (IF: 3.562)
8) Triaryl-substituted Schiff Bases are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor. Zong-Quan Liao, Chune Dong, Kathryn E. Carlson, Sathish Srinivasan, Jerome C. Nwachukwu, Robert W. Chesnut, Abhishek Sharma, Kendall W. Nettles, John A. Katzenellenbogen,* and Hai-Bing Zhou*. J. Med. Chem. 2014, 57 (8), 3532-3545. (IF: 5.447)
9) C3-Symmetric Cinchonine-Squaramide-Catalyzed Asymmetric Chlorolactonization of Styrene-Type Carboxylic Acids with 1,3-Dichloro-5,5-dimethylhydantoin: An Efficient Method to Chiral Isochroman-1-ones. Xin Han, Chune Dong, and Hai-Bing Zhou*. Adv. Synth. Catal.2014, 356 (6), 1275–1280. (IF: 5.663).
10) One-pot to fused pyrazoles by a double cyclization of o-alkynylaldehydes with ketones and hydrazine under metal-free condition, Jinxia Qiao, Bin Liu, Zongquan Liao, Ying Li, Lei Ma, Chune Dong, and Hai-Bing Zhou*. Tetrahedron 2014, 70 (24), 3782-3787. (IF: 2.641)
11) Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts. Xin Han, Wenjie Ouyang, Bin Liu, Wei Wang*, Po Tien, Shuwen Wu*, Hai-Bing Zhou*. Org. Biomol. Chem., 2013, 11 (48), 8463-8475. (IF: 3.487)
12) Design, Synthesis and Biological Evaluation of Novel Estrogen-derived Steroidal Metal Complexes. Xinlong Zhang, Ziqing Zuo, Juan Tang, Kai Wang, Caihua Wang, Weiyan Chen, Changhao Li, Wen Xu, Xiaolin Xiong, Kangxiang Yuntai, Jian Huang, Xiaoli Lan, Hai-Bing Zhou*. Bioorg. Med. Chem. Lett.2013, 23(13), 3793-3797. (IF: 2.331)
13) Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity. Jian Min, Pengcheng Wang, Sathish Srinivasan, Jerome C. Nwachukwu, Pu Guo, Minjian Huang, Kathryn E. Carlson, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. J. Med. Chem., 2013,56 (8), 3346–3366. (IF: 5.480)
14) Identification and Structure-Activity Relationships of a Novel Series of Estrogen Receptor Ligands Based on 7-Thiabicyclo[2.2.1]hept-2-ene-7-oxide. Pengcheng Wang, Jian Min, Jerome C. Nwachukwu, Valerie Cavett, Kathryn E. Carlson, Pu Guo, Manghong Zhu, Yangfan Zheng, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. J. Med. Chem. 2012, 55(5), 2324-2341. (IF: 5.614)
15) An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3-Symmetric Cinchonine-Squaramide Catalysts. Xin Han, Xiangfei Wu, Chang Min, Hai-Bing Zhou, Chune Dong*. RSC Advances 2012, 2 (19), 7501-7505.
16) Synthesis, biological evaluation and structure activity relationships of new estrogen receptor ligands based on a bridged oxabicyclic core embellished with arylsulfonamides. Manghong Zhu, Chen Zhang, Jerome C. Nwachukwu, Sathish Srinivasan, Valerie Cavett, Yangfan Zheng, Kathryn E. Carlson, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. Org. Biomol. Chem., 2012, 10(43), 8692-8700. (IF: 3.568)
17) Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells. Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Wenming Ren, Chune Dong, Jian Huang*, Hai-Bing Zhou*. Org. Biomol. Chem., 2012, 10(48), 9689-9699. (IF: 3.568)
18) Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2.2.1]hept-5-ene Scaffold Core Ligands. Yangfan Zheng, Manghong Zhu, Sathish Srinivasan, Jerome C. Nwachukwu, Valerie Cavett, Jian Min, Kathryn E. Carlson, Pengcheng Wang, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. ChemMedChem2012, 7 (6), 1094-1100. (IF: 2.835)
19) C3-Symmetric Cinchonine-Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition. Chang Min, Xin Han, Zongquan Liao, Xiangfei Wu, Hai-Bing Zhou, Chune Dong*. Adv. Synth. Catal. 2011, 353 (14-15), 2715–2720. (IF: 6.048).
20) Metal-free Direct Amidation of Peptidyl Thiol Esters with α-Amino Esters. Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng. Green. Chem. 2011, 13, 2723-2726. (IF: 6.320)
21) Imaging progesterone receptor in breast tumors: Synthesis and receptor binding affinity of fluoroalkyl-substituted analogs of Tanaproget.Hai-Bing Zhou, Jae Hak Lee, Christopher G. Mayne, Kathryn E. Carlson, John A. Katzenellenbogen*, J. Med. Chem. 2010, 53 (8), 3349–3360. (IF: 5.207)
22) Development of [F-18]Fluorine-Substituted Tanaproget as a Progesterone Receptor Imaging Agent for Positron Emission Tomography. Jae Hak Lee, Hai-Bing Zhou, Carmen S. Dence, Kathryn E. Carlson, Michael J. Welch, John A. Katzenellenbogen*, Bioconjugate Chem. 2010, 21 (6), 1096-1104. (IF: 5.002)
23) Analogs of methyl-piperidinopyrazole (MPP): Antiestrogens with estrogen receptorselective activity. Hai-Bing Zhou, Kathryn E. Carlson, Fabio Stossi, Benita S. Katzenellenbogen, John A. Katzenellenbogen*. Bioorg. Med. Chem. Lett. 2009, 19 (1), 108-110. (IF: 2.650)
24) Bromination from the Macroscopic Level to the Tracer Radiochemical Level: 76Br Radiolabeling of Aromatic Compounds via Electrophilic Substitution. Dong Zhou, Haibing Zhou, Carl C. Jenks, Jason S. Lewis, John A. Katzenellenbogen, and Michael J. Welch*. Bioconjugate Chem. 2009, 20 (4) 808-816. (IF: 4.350)
25) NFkB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. K. W. Nettles*, J. B. Bruning, G. Gil, J. Nowak, S. K. Sharma, J. B. Hahm, K. Kulp, R. B. Hochberg, H. B. Zhou, J. A. Katzenellenbogen, B. S. Katzenellenbogen, Y. Kim, A. Joachmiak, G. G. Greene, Nature Chemical Biology 2008, 4 (4), 241-247. (IF: 14.612)
26) Elemental Isomerism: A Boron-Nitrogen Surrogate for a Carbon-Carbon Double Bond Increases the Chemical Diversity of Estrogen Receptor Ligands. Hai-Bing Zhou, Kendall W. Nettles, John B. Bruning, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, Fabio Stossi, Benita S. Katzenellenbogen, Geoffrey L. Greene and John A. Katzenellenbogen*, Chemistry & Biology 2007, 14 (6), 659-669. (IF: 5.718)
27) Bicyclo[2.2.2]octanes: Close Structural Mimics of the Nuclear Receptor-binding Motif of Steroid Receptor Coactivators. Hai-Bing Zhou, Margaret L. Collins, Jillian R. Gunther, John S. Comninos and John A. Katzenellenbogen*, Bioorg. Med. Chem. Lett. 2007, 17 (15), 4118-4122. (IF: 2.604)
28) Structure-Guided Optimization of Estrogen Receptor Binding Affinity and Antagonist Potency of Pyrazolopyrimidines with Basic Side Chain. Hai-Bing Zhou, Shubin Sheng, Dennis R. Compton, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, B. S. Katzenellenbogen, Kendall W. Nettles, Geoffrey L. Greene and John A. Katzenellenbogen*, J. Med. Chem. 2007, 50 (2), 399-403. (IF: 4.895)
29) Synthesis and Evaluation of Estrogen Receptor Ligands with Bridged Oxabicyclic Cores Containing a Diarylethylene Motif: Estrogen Antagonists of Unusual Structure. Hai-Bing Zhou, John S. Comninos, Fabio Stossi, Benita S. Katzenellenbogen, and John A. Katzenellenbogen*, J. Med. Chem. 2005, 48 (23), 7261-7274.
