Faculty

Kui Hong
Author:  Date:November 9, 2016  Click:

PROFILE

Name: Kui Hong

Subjects:Marine microbial drug discovery

Department: School of Pharmaceutical Sciences

College appointment: Professor

Email: kuihong31 @whu.edu.cn

Telephone: 86-27-68752442

Fax: 86-27-68752442

Web-page:

 

◆Background/Biography:

·Education:

09/95-07/98: Ph D, Department of Biological Sciences and Biotechnology Tsinghua University, Beijing/China, and Department of Microbiology, Nanjing Agriculture University, Supervisors: Professors CHEN Guo-Qiang, HUANG Weiyi and FAN Qingsheng

09/88-07/91: M.Sc. Department of Tropical Crops Procession. South China College of Tropical Crops. Supervisor: Professor HU Guanglie

09/84-07/88: B. Sc, Microbiology Specialty, Department of Biology, Wuhan University,

·Honors & Awards:

Ministry of China Education, Program for New Century Excellent Talents in University,2005

Royal Society of UK, China Fellow,2004

Key University Young Teacher of China Education Ministry,2000

Hainan Outstanding Middle and Young Aged University Teachers (one of ten, for the first time in Hainan province),2000

Hainan Ten Excellent youth in 2000

◆Teaching: Microbiology

◆Research interests:

1)        Druggability evaluation of marine microbial natural products

2)        Terpene biosynthesis of marine fungi: pathway, gene function and synthetic biology

3)        Genomics guided microbial natural products discovery and biosynthesis

4)        Microbial systematic guided microbial drug resources (culture, compounds and genes): collection, isolation and identification

◆Publications: (representative publications in 2016, 2015)

1.        Ying Han , Erli Tian , Dongbo Xu, Min Ma, Zixin Deng and Kui Hong. Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807. Molecules 2016, 21, 970; doi:10.3390/molecules21080970

2.        Chai H, Yin R, Liu Y, Meng H, Zhou X, Zhou G, Bi X, Yang X, Zhu T, Zhu W, Deng Z, Hong K. Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus. Sci Rep. 2016 Jun 7; 6:27181. doi: 10.1038/srep27181.

3.        Mostafa E. Rateb, Yin Zhai, Emmanuelle Ehrner, Christopher M. Rath, Xiaoling Wang, Jioji Tabudravu, Rainer Ebel, Mervin Bibb, Kwaku Kyeremeh, Pieter C. Dorrestein, Kui Hong,* Marcel Jaspars*, Hai Deng*. Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate.  Organic & Biomolecular Chemistry, 2015. DOI: 10.1039/c5ob01269d

4.        Zhang L, Ruan C, Peng F, Deng Z, Hong K. Streptomyces arcticus sp. nov., isolated from the Arctic. Int J Syst Evol Microbiol. 2016 Jan 19. doi: 10.1099/ijsem.0.000907. [Epub ahead of print]

5.        Xie QY, Ren J, Li L, Li Y, Deng ZX, Hong K. Micromonospora mangrovi sp. nov., isolated from mangrove soil. Antonie Van Leeuwenhoek. 2016 Apr;109(4):483-91. doi: 10.1007/s10482-015-0641-x. Epub 2016 Mar 4

6.        Xu D, Ma M, Liu Y, Zhou T, Wang K, Deng Z, Hong K*. PreQ0 base, an unusualmetabolite with anti-cancer activity from Streptomyces qinglanensis 172205. Anticancer Agents Med Chem. 2015;15(3):285-90.

7.        Xu DB, Ma M, Deng ZX, Hong K*. Genotype-driven isolation of enterocin withnovel bioactivities from mangrove-derived Streptomyces qinglanensis 172205. Appl Microbiol Biotechnol. 2015 Jul; 99(14):5825-32. doi: 10.1007/s00253-015-6574-5. Epub 2015 Apr 17

8.        Yin Zhai, Bin Cheng, Juan Hu, Kwaku Kyeremeh, Xiaoling Wang, Marcel Jaspars, Hai Deng, Zi-Xin Deng, Kui Hong, Draft genome sequence of Streptomyces sp. strain CT34, isolated from a Ghanaian soil sample, Genome announcements, 2015 Feb 5;3(1). pii: e01508-14. doi: 10.1128/genomeA.01508-14

9.        Lv C, Qin W, Zhu T, Wei S, Hong K, Zhu W, Chen R, Huang C. Ophiobolin O isolated from Aspergillus ustus induces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/cyclin D1 signaling. Mar Drugs. 2015 Jan 16;13(1):431-43. doi: 10.3390/md13010431.

10.    Xu DB, Ye WW, Han Y, Deng ZX, Hong K*. Natural Products from Mangrove Actinomycetes. Marine Drugs. 2014, 12, 2590-2613; doi:10.3390/md12052590

Contact Us

  • School of Pharmaceutical Sciences,Wuhan University
  • Address: NO.185 Donghu Road, Wuchang District,Wuhan, 430071, China
  • Phone: +86-27-68759987
  • Fax: +86-27-68759850
  • Email: wdyxy@whu.edu.cn

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