Name: Meijia Gu
Subjects：Cell Biology
Department: School of Pharmaceutical Sciences
College appointment: Lecturer
Email: mjgu@whu.edu.cn
Telephone: 027-68752435
EDUCATION
2006.09-2011.05 M.S.-Ph.D. (College of Life Sciences, Wuhan University)
Major: Microbiology
Adviser: Congyi Zheng
Professor
Phone.: +86-27-68754001
E-mail: cctcc202@whu.edu.cn
Ph. D Degree Project: The alternative splicing of breast cancer associated Gene BRCA1 and the functions of these splicing variants.
2010.01-2010.11 Visiting Scholar (Department of Pathology, Ohio State University, Columbus)
Adviser: Xianghong Zou
Assistant Professor
Phone: (614) 688-8424.
Email: zou.32@osu.edu
Project: Studies on cell cycle factor Cdk4-related projects and breast cancer research.
2002.09-2006.07 B.S. Degree (College of Life Sciences, Wuhan University)
Major: Biotechnology
College of Life Sciences, Wuhan University, China
EMPLOYMENT
2014.01-Present Lecturer (School of Pharmaceutical Sciences, Wuhan University)
Duties: Research and education
2014.09- 2015.10 Postdoc (Dana Farber Cancer Institute, Harvard Medical School)
Mentor: Rosalind Segal, MD, PhD
Professor
Phone: 617-632-4737
E-mail： rosalind_segal@dfci.harvard.edu
Postdoc Project: The molecular mechanisms of Sonic Hedgehog gene in development
2011.06- 2013.12 Postdoc (School of Pharmaceutical Sciences, Wuhan University)
Mentor: Shi Chen
Professor
Phone: +86-27-68752435
E-mail：shichen@whu.edu.cn
Postdoc Project: The molecular mechanisms of Sonic Hedgehog gene in development
Teaching:
Advances in biological pharmacy
Grants
1. The National Program on Key Basic Research Project of China (973 Program); (PI for sub-subject, Grant No. 2013CB734003)
2. The National Natural Science Foundation of China (PI, Grant No. 31300038)
3. The China Postdoctoral Science Foundation (PI, Grant No. 2013M542052)
4. Research Fund of Higher Education of China (PI, Grant No. 306-274532)
5. Faculty Research Development Fund of Wuhan University (PI, Grant No. 306-230189)
Research interests:
1. Amyotrophic lateral sclerosis (ALS) is one of the most common progressive disorders of the motor system. We intended to establish gene knockout rat model, then study the pathological changes of nervous system, behavioral change and develop the method to primary culture spinal cord motor neurons from rat, build ALS rat model for drug screening.
2. Molecular mechanism of Sonic Hedgehog gene in development.
3. Molecular biology of DNA backbone modification – DNA phosphorothioation
Publications:
1. Chongde Lai, Xiaolin Wu, Chao Chen, Teng Huang, Xiaolin Xiong, Shuangju Wu, Meijia Gu, Zixin Deng,1 Xi Chen, Shi Chen and Lianrong Wang. (2014). In Vivo Mutational Characterization of DndE Involved in DNA Phosphorothioate Modification
2. Gu MJ, Li H, Shen C, Wu L, Liu WH, Miao LX, Zheng CY.(2010). Cloning and characterization of a new BRCA1 variant: A role for BRCT domains in apoptosis. Cancer Letters. 295 (2):205-13.
3. Shen C, Gu MJ, Song C, Miao LX, Hu L, Liang D, Zheng CY.(2008). The tumorigenicity diversification in human embryonic kidney 293 cell line cultured in vitro. Biologicals. 36(4): 263-268.
4. Shen C, Gu MJ, Liang D, Miao LX, Hu L, Zheng CY, Chen J.(2009). Establishment and characterization of three new human breast cancer cell lines derived from Chinese breast cancer tissues. Cancer Cell International. 9:2.
5. Miao LX, Cao ZJ, Shen C, Gu MJ, Liu WH, Li H, Zheng CY.(2008). Cloning and Functional Identification of Two Novel BRCA1 Splicing Variants. Biochemistry (Moscow), 73(11): 1214-1223.
6. Shen C, Gu MJ, Zheng CY. (2009). Establishment and characterization of three human breast cancer cell lines derived from Chinese breast cancer tissues. The 11th Cell Congress of Chinese Society for Cell Biology.
