Name: Weixin tao
Subjects: Biochemistry and Molocular Biology
Department: School of Pharmaceutical Sciences
College appointment: Lecturer
Email: taoweixin@whu.edu.cn
Telephone: 18986037807
Background/Biography:
2013/12- now School of Pharmaceutical Sciences, Wuhan University, Lecturer
2011/11-2013/11 School of Basic Medical Sciences, Wuhan University, Post-Doctor
2008/9-2011/7 College of Natural Resources and Life Science, Dong-A University (Korea), PhD of Science
2006/10-2008/9 R&D department, GuangZhou ZhongDa Marine Biotechnology Center of South China Sea co., LTD
2003/9-2006/6 College of Life Science, HuaZhong Agricultural University, Master of Science
1999/9-2003/6 College of Life Science, HuaZhong Agricultural University, Bachelor of Science
Teaching:
Biochemical Experiment
Molecular Biology
Research interests:
Biosynthetic investigation of the microbial natural products:
1. Mining novel biosynthetic gene clusters using biotechnologies like comparative genomics, metagenomics etc.
2. Understanding/optimizing the biosynthetic pathway of microbial natural products by elucidating the biochemical mechanism of the key biosynthetic steps.
Publications:
1． Tao, W.X.,* Yurkovich, M.E.,* Wen, S.S.,* Lebe, K.E., Samborskyy, M., Liu, Y.Z., Yang, A.N., Liu, Y.K., Ju, Y.C., Deng, Z.X., Tosin, M., Sun, Y.H. and Leadlay, P.F. (2015) A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chem Sci. DOI:10.1039/c5sc03059e. (*co-first author)
2． Wu, J., Kong, H.G., Jung, E.J., Choi, S.Y., Lee, H.J., Tao, W.X., Chung, E.S. and Lee, S.W. (2015) Loss of glutamate dehydrogenase in Ralstonia solanacearum alters dehydrogenase activity, extracellular polysaccharide production and bacterial virulence. Physiol Mol Plant P. 90:57-64
3． Liu, Y.K.,* Tao, W.X.,* Wen, S.S., LI, Z.Y., Yang, A.N., Deng, Z.X. and Sun, Y.H. (2015) In vitro CRISPR/Cas9 system for efficient targeted DNA editing. mBio. 6(6):e01714-15.
4． Tao, W.X.,* Zhu, M.H.,* Deng, Z.X. and Sun, Y.H. (2013) Biosynthesis of Tetronate Antibiotics: A Growing Family of Natural Products with Broad Biological Activities. Sci China Chem. 56(10):1364-1371.
5． Kanchanabanca, C.,* Tao, W.X.,* Hong, H., Liu, Y.J., Hahn, F., Samborskyy, M., Deng, Z.X., Sun, Y.H. and Leadlay, P.F. (2013) Unusual acetylation-elimination in the formation of tetronate antibiotics. Angew Chem Int Edit. 52(22):5785-5788.
6． Tao, W.X., Lee, M.H., Wu, J., Kim, N.H., Kim, J.C., Chung, E.S., Hwang, E.C. and Lee, S.W. (2012) Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase. Appl Environ Microbiol. 78(17):6295-6301.
7． Tao, W.X., Lee, M.H., Yoon, M.Y., Kim, J.C., Malhotra, S., Wu, J., Hwang, E.C. and Lee, S.W. (2011) Characterization of two metagenome-derived esterases that reactivate chloramphenicol by counteracting chloramphenicol acetyltransferase. J Microbiol Biotechnol. 21(12):1203-1210.
8． Tao, W.X., Lee, M.H., Wu, J., Kim, N.H. and Lee, S.W. (2011) Isolation and characterization of a family VII esterase derived from alluvial soil metagenomic library. J Microbiol. 49(2):178-185.
9． Lee, M.H., Hong, K.S., Malhotra, S., Park, J.H., Hwang, E.C., Choi, H.K., Kim, Y.S., Tao, W.X. and Lee, S.W. (2010) A new esterase EstD2 isolated from plant rhizosphere soil metagenome. Appl Microbiol Biotechnol. 88(5):1125-1134.
10． Li, W.C.,* Wu, J.,* Tao, W.X., Zhao, C.H., Wang, Y.M., He, X.Y., Chandra, G., Zhou, X.F., Deng, Z.X., Chater, K.F. and Tao, M.F. (2007) A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiol Lett. 266(1):20-28.
11． Tao, W.X., Wu, J., Deng, Z.X. and Tao, M.F. (2007) Cloning of bldAa and the effect on morphological differentiation and avermectins production in Streptomyces avermitilis NRRL8165. Acta Microbiol Sin. 47(1):34-38.
